Presented at: American College of Cardiology Scientific Session April 2-4, 2016 Chicago.ĭisclosure: Bittner reports no relevant financial disclosures. “Also, the additional incremental risk of CCTA beyond that of CAC is very minimal nowadays.” – by Julie Gotchelīittner Daniel O, et al. The discriminative potential of risk scores was analyzed using the area under the receiver-operating characteristics curve (AUC). The patients admitted with non-ST elevation acute coronary syndrome were evaluated to calculate the GRACE and TIMI risk score. The TIMI, GRACE, PAMI, and CADILLAC risk scores were calculated. “It is not meant to be a substitute for CCTA because we know that CCTA has a very high predictive value and excellent accuracy,” he said. Method The cross-sectional study done in the Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka, Bangladesh from April, 2015April, 2016. Though not intended to be a replacement for CCTA, prior coronary artery calcification scans can contain valuable information regarding evaluation of patients with acute chest pain.īittner said that although the results are positive, the combination should not completely replace CCTA. The positive predictive value for a combination of presence of any CAC and TIMI score > 0 to predict ACS was 13.1%. When combined with the TIMI score, the negative predictive value of TIMI score was 0 and no CAC was 100.0% for ≥70% stenosis and ACS. The negative predictive value of CAC was 99.8% for ≥70% stenosis and 99.5% for ACS. “So there is risk for misclassification, and that’s why we sought to determine the predictive value of the combination of coronary artery calcification together with TIMI risk scoring for this acute chest pain population.”īittner and colleagues evaluated 826 consecutive patients (mean age, 52.6 years 41.9% female) who underwent CTA. Bittner, MD, a fellow at Massachusetts General Hospital, told Cardiology Today. “What we know is that the negative predictive value of coronary artery calcification is very high, but the risk for a future event is not zero,” Daniel O. When used in combination, the scoring system may be applicable in situatuions where coronary computed tomography angiography is not available and a coronary artery calcification score is known, according to the researchers. If you continue to have this issue please contact to HealioĬoronary artery calcification scoring in combination with clinical risk assessment using the TIMI score reliably identified patients at risk for acute coronary syndrome and coronary artery disease, according to data presented at the American College of Cardiology Scientific Session. GRACE and PURSUIT risk scores had more correlation with angiographic extent of CAD.Īngiographic severity GRACE score Modified gensini score PURSUIT score TIMI score.We were unable to process your request. Hence we recommend that these factors be given more importance. Use of Aspirin, age >= 65 years, presence of CHF and presence of elevated enzymes are stronger predictors of extent of CAD. GRACE score had better correlation with Modified Gensini score, PURSUIT score had more correlation with percentage stenosis in culprit artery. Background Despite women undergoing primary percutaneous coronary intervention (PPCI) having a higher rate of adverse outcomes than men, data evaluating prognostic risk scores, especially in elderly women, remains scarce. Presence of elevated enzymes and age >65 years were more significant predictors of percentage stenosis of culprit artery. Use of aspirin, age >= 65 years & presence of Congestive Heart Failure (CHF) were stronger predictors of Modified Gensini score. ![]() Multiple linear regressions, Student's t-test and Pearson's coefficient 'r' were also used. Correlation with Modified Gensini score and percentage stenosis in culprit artery was done.ĭata were summarized in the form of Mean, Standard Deviation and Proportions. All patients underwent coronary angiography. One hundred and sixty patients with acute unstable angina were evaluated for presence of 9 clinical predictors and their 3 risk scores were calculated. This was a hospital based single centre, cross-sectional, observational, descriptive study conducted at a tertiary care teaching institute. ![]() To know the correlation of clinical risk scores with angiographic extent of coronary artery disease. The correlation of clinical risk predictors and clinical risk scores: Thrombolysis in Myocardial Infarction (TIMI), Platelet Glycoprotein IIb-IIIa in Unstable Angina, Receptor Suppression Using Integrilin Therapy (PURSUIT) and Global Registry of Acute Coronary Events (GRACE) scores in Unstable Angina with angiographic extent of Coronary Artery Disease (CAD) is not known.
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